ABSTRACT
A sixty-eight-year-old woman with documented sick sinus syndrome was found to have, five years later, florid clinical features of systemic amyloidosis which only then led to recognition of an underlying IgA, Kappa paraproteinaemia. The literature on this association is outlined. Underlying plasma cell dyscrasias should be excluded in cases of unexplained sick sinus syndrome.
Subject(s)
Humans , Middle Aged , Female , Amyloidosis/diagnosis , Amyloidosis/therapy , Sick Sinus Syndrome/etiology , Sick Sinus Syndrome/therapy , Paraproteinemias/therapy , Trinidad and TobagoABSTRACT
A pre-menopausal patient with a six-year history of symptoms of the metastatic carcinoid syndrome leading to progressively worsening carcinoid heart disease is described. The failure of anti-oestrogenic therapy (sequential bilateral oophorectomy and Tamoxifen therapy) to halt progression of disease was documented. Death resulted from right ventricular failure associated with pulmonary and tricuspid valvular disease
Subject(s)
Humans , Middle Aged , Female , Tamoxifen/therapeutic use , Malignant Carcinoid Syndrome/drug therapy , Tamoxifen/adverse effects , Biopsy , Malignant Carcinoid Syndrome/diagnosis , Malignant Carcinoid Syndrome/pathologyABSTRACT
Twenty patients with Acquired Immune Deficiency Syndrome (AIDS) received treatment with Inosine Pranobex and specific antibacterial and anti-parasitic therapy. Five died shortly after hospitalization, but a further fifteen who also received ACTH, survived, gained weight and improved and clinically, biochemically and haematologically